Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2
نویسندگان
چکیده
منابع مشابه
Gene × gene and gene × environment interactions for complex disorders
The restricted partition method (RPM) provides a way to detect qualitative factors (e.g. genotypes, environmental exposures) associated with variation in quantitative or binary phenotypes, even if the contribution is predominantly an interaction displaying little or no signal in univariate analyses. The RPM provides a model (possibly non-linear) of the relationship between the predictor covaria...
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Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level genetic changes take many generations to occur, this epidemic is almost certainly primarily a consequence of recent environmental changes; nonetheless, diabetes does appear to occur preferentially in genetically predisposed populations, which suggests that the effects of pre-existing susceptibility genes hav...
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Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland. Institute of Genetics and Genomics in Geneva, University of Geneva, Geneva, Switzerland. Swiss Institute of Bioinformatics, Geneva, Switzerland. Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. Department of Genetics, Stanford University, Stanford, California, USA. Department of Twi...
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There has been an increasing interest in detecting gene-gene and gene-environment interactions in genetic association studies. A major statistical challenge is how to deal with a large number of parameters measuring possible interaction effects, which leads to reduced power of any statistical test due to a large number of degrees of freedom or high cost of adjustment for multiple testing. Hence...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2012
ISSN: 1471-2105
DOI: 10.1186/1471-2105-13-132